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Comparison with Other Medications Tirzepatide has been compared with other popular diabetes and weight loss medications, including: Semaglutide Dulaglutide Insulin glargine In a 2021 meta-analysis , tirzepatide outperformed these drugs in controlling blood sugar and promoting weight loss

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However, Mounjaro and Zepbound are approved for different health concerns: Mounjaro for type 2 diabetes management , whereas Zepbound serves those aiming for weight management under specific conditions like obesity or related health concerns

The most commonly known incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), formerly called Gastric inhibitory peptide (29, 30)

Factors to Weight Loss Resistance Several factors contribute to weight loss resistance, including thyroid and sex hormone imbalances, lack of exercise, chronic sleep deprivation, metabolic slowdown from chronic dieting, food allergies, gut dysbiosis, high cortisol levels due to chronic stress, insulin resistance, and exposure to environmental toxins