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Compr Psychiatry

Absolute body weight reductions measured 10.2, 12.9, and 13.1 kg across the 2.4, 4.8, and 6 mg cohorts respectively vs

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However, over time clinicians also began observing several important challenges: Weight loss plateaus Metabolic adaptation Lean mass loss Reduced energy expenditure Long-term maintenance difficulty These observations helped shift the conversation toward broader metabolic regulation rather than appetite suppression alone

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