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Before semaglutide, other GLP-1 drugs, like liraglutide, had faltered in clinical trials

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Meshkat S, Di Luciano C, Swiderski A, Li G, Aguilar RJ, Dunkley BT, Reichelt AC, Zhang Y, Greenshaw A, Vermetten E, Jetly R, Dash S, Agarwal SM, Swainson J, Bhat V (2025) Efficacy and Safety of Glucagon-Like Peptide-1 Agonists for Psychiatric Symptoms: A Systematic Review