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iScience (2021) 24:103382
Knockout of inositol-requiring enzyme 1 in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure
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So in 2014, the FDA began approving these medications for weight loss first Saxenda (liraglutide) , then Wegovy (semaglutide) , Zepbound (tirzepatide) , and most recently, Foundayo (orforglipron)
Tan Q, Akindehin SE, Orsso CE, et al
