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In a 2021 study published in the New England Journal of Medicine, participants taking Semaglutide lost an average of 14.9% of their body weight over 68 weeks

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This case highlights the need for gradual insulin tapering and close monitoring while transitioning from insulin therapy to GIP/GLP-1 receptor agonists.

Beyond these frontrunners, the pipeline is expanding: Novo Nordisk filed for FDA approval of CagriSema in 2025, the first once-weekly combination of GLP1 and amylin analogue

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