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These experiences are real, measurable, and directly linked to hormonal changes [8]

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In EAE, inflammation and activation of the inflammasome are initiated by the binding of pathogen-associated molecular patterns (PAMP) or danger-associated molecular patterns (DAMP), like the high mobility group box protein-1 (HMGBP) that is released to the extracellular environment from the activated macrophages, monocytes, dendritic cells as well as apoptotic oligodendrocytes (highly expressed in relapsing-remitting MS (RRMS) patients) [128,129,130]

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In clinical trials of oral GLP1 medications, digestive symptoms were the most frequently reported side effects, occurring at rates similar to those seen with injections

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