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2 The addition of semaglutide to the Food and Drug Administration (FDA) shortage list from 2022 to February 2025, and tirzepatide to the same list from 2022 to December 2024, gave compounding pharmacies permission by the FDA to produce exact duplicates to ensure continuity of treatment until production met demand

Margulies KB, Hernandez AF, Redfield MM, Givertz MM, Oliveira GH, Cole R, Mann DL, Whellan DJ, Kiernan MS, Felker GM, et al

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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)