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Description
GLP-1 receptors are present in the hypothalamus, and when GLP-1 rises after a meal, it acts directly on the hypothalamus to reduce the alerting signal from orexin neurons
2024;74:102726 (in English)
In humans, fasting systemic plasma concentrations of total GLP-1 (including metabolites generated by DPP-4-mediated degradation) are typically in the range of 510 pmol/L and can increase up to 40 pmol/L in response to a meal [236]
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They have not undergone the rigorous pre-market review process that FDA-approved medications complete
