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Figure 1 3.3 Association between GLP-1RA exposure and opioid use disorder Exposure to any GLP-1 RAs was significantly associated with reduced odds of OUD diagnosis
The mechanism becomes especially concerning for semaglutide users who do not realize they need to dramatically increase their water intake to compensate for GI losses and suppressed thirst signals
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This may be of benefit for anyone with MCAS, and clinical trials are looking at the effectiveness of different doses.[ref][ref] Dementia prevention: Studies using data from diabetes patients showed a significant decrease in dementia for those on GLP-1s vs other diabetes medications

At Digbi Health, our Precision Biologydriven Lifestyle Care program mirrors the breadth of GLPs, tackling obesity, type 2 diabetes, digestive disorders, and mental health through gut microbiome, genetics, and continuous glucose monitoring

BMJ 348:g1416 Becker WJ (2017) The Diagnosis and Management of Chronic Migraine in Primary Care
