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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art

Due to the above-mentioned effects of TZD on glycemic, hepatic metabolism, and inflammation, treatment with dual-agonism may reduce or reverse liver damage (lobular inflammation, hepatic steatosis, liver cell damage, and fibrosis) and metabolic dysfunction ( GLP-1RA has multiple hepatic effects on MAFLD, involving an adaptation of portal and plasma glucagon and insulin concentrations, hepatic insulin sensitivity and improving hepatocyte mitochondrial function ( There is a randomized controlled phase 2 study with the objective to explore the use of TZP as a treatment for MAFLD, providing strong evidence [NCT04166773]

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If you suspect freezing exposure, do not use the medication