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For a compound with as many ongoing trials as retatrutide, deciding which data to include and which to reference as pending is a strategic decision

It belongs to a novel class of agents known as triple agonists , meaning it simultaneously activates three distinct hormone receptors: GIP receptor (glucose-dependent insulinotropic polypeptide) GLP-1 receptor (glucagon-like peptide-1) Glucagon receptor This triple mechanism of action distinguishes retatrutide from currently approved agents such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

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As of 2026, the sole FDA-approved indication for tesamorelin (Egrifta, Egrifta SV, Egrifta WR) is the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy

In contrast, the FREEDOM trial reported that the constant infusion of exenatide (20 ug daily for 3 months followed by 60 g daily) through an osmotic minipump was non-inferior to the placebo in 4156 T2DM patients (with a median follow-up of 16 months) (Ruff et al