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The mechanism involves activation of PKC, ERK, and CaM kinase II pathways, as well as GPR40/120 receptors on L-cells (Takikawa et al., 2019)

Obesity contributes to renal damage through hemodynamic changes, including glomerular hyperfiltration and increased renal plasma flow, which over time lead to glomerular hypertrophy and focal segmental glomerulosclerosis (4)

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doi: 10.2337/diabetes.52.2.268 54 CarrNSolomonGGertlerABinartN