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Neuropharmacology 123 , 6779, (2017)

These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

Contraception advice is essential for women of childbearing potential using Wegovy, as effective contraception is required during treatment

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Findings This cohort study of 185 066 individuals prescribed treatment with GLP-1 RAs revealed an association with slightly higher risk of developing incident DR but a similar incidence of NAION and fewer serious DR-associated complications, including new-onset blindness