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[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Rosenstock J, Wysham C, Fras JP, Kaneko S, Lee CJ, et al

The most common side effects are gastrointestinal (think: constipation, diarrhea, or an upset stomach)

Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Overall, the favorable metabolic profile induced by GLP-1 RAs (weight loss and reduced caloric intake, improvement in glycemic compensation) allows one to hypothesize their potential effectiveness in the treatment of NAFLD, in addition to T2DM and obesity

Rotating injection sites with each weekly dose prevents repeated trauma to the same area and allows previous injection sites to heal completely