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Many patients experience gastrointestinal side effects during treatment, particularly in the initial weeks, and caffeine can sometimes exacerbate certain symptoms

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The reasons for the discrepancy between pro-C3 and ELF results are not entirely clear but may reflect the fact that the ELF test is a proprietary algorithm based on three fibrosis biomarkers (hyaluronic acid, procollagen III amino acid terminal peptide and tissue inhibitor of metalloproteinase 1), whereas pro-C3 is a single biomarker targeting the N-terminal pro-peptide of type III collagen by a different epitope than the procollagen III amino acid terminal peptide assay included in the ELF test

Notably, two new glucagon-like peptides were identified in intestinal extracts: GLP-1 and GLP-2

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