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The neuron-specific deletion of SOCS3 increases leptin sensitivity through STAT3 activation, indicating that SOCS3 is an important negative feedback regulator of leptin signaling [99, 100]
Statistical analyses were carried out with GraphPad Prism 10.0 software
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The use of different critical appraisal tools allowed us to evaluate each according to its design, but direct comparison of findings across these diverse methodologies remains challenging
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