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1 Introduction Psoriasis (PsO) is a chronic, immune-mediated inflammatory skin disorder affecting 23% of the global population ( In parallel with this evolving disease concept, growing evidence points to a complex immunometabolic interplay linking dysregulated glucose metabolism, incretin biology, and chronic inflammation in PsO ( Within this framework, incretins particularly glucagon-like peptide-1 (GLP-1) have emerged as key immunometabolic regulators rather than merely glucose-lowering hormones

Tirzepatide is a dual GIP and GLP-1 receptor agonist licensed in the UK for type 2 diabetes and weight management

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