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Acknowledgments The author declared that there is no conflict of interest

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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

However, this tertiary structure disappeared when exendin-4 was bound to DPC micelles, since the indole ring of Trp is energetically more favored to associate with the hydrophobic micelles

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