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doi: 10.1016/j.lfs.2020.118548 [DOI] [PMC free article] [PubMed] [Google Scholar] 177.Saengboonmee C, Sorin S, Sangkhamanon S, et al

Liraglutide acts on the GLP-1 receptor and has the longest prescribing track record of the three, having been approved for weight management since 2014
Somewhat paradoxically, a final nonsurgical treatment that we believe should be considered in some patients is targeted lipolysis, for example using deoxycholic acid or cryolipolysis

This drops cortisol by 10-15% and soothes anxiety-driven hunger

Retatrutide appears to push the boundaries further with its third receptor target
