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Exacerbation of GERD with initial use of GLP-1 therapies may be managed with short-term use of proton pump inhibitors or H2 receptor antagonists, noting that weight reduction achieved with GLP-1 therapies over the long-term often leads to improvement in GERD symptoms [34,35]

Indeed, a once-every-four-month therapy is likely to be ideal for clinical diabetes management, as this would align with the typical cadence with which patients visit their endocrinologist or personal care provider

an endocrinologist the phase 2 trial demonstrates that Retatrutide might be more potent for regulating hunger, quoted as "the most effective anti-obesity med to date." How Retatrutide Works 1.Astric inhibitory polypeptide receptor (GIPR) agonist As a GIP receptor agonist, retatrutide enhances appetite suppression and prevents fat accumulation, resulting in decreased energy intake and increased energy expenditure

The researchers note that people previously treated with tirzepatide generally lost more total weight initially, which may partly explain the larger rebound