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Most participants experienced rapid initial loss during the first 12 weeks as their bodies responded to appetite suppression

Weight loss caused by taking Orlistat may improve blood sugar control for diabetics, while also modestly reducing the onset of type 2 diabetes and blood pressure, both at similar levels caused by positive changes in lifestyle and diet

[DOI] [PubMed] [Google Scholar] 18.Guzman-Perez A, et al

445 participants: 12 mg: average 28.7% body weight loss WOMAC knee pain scores dropped by up to 75.8% More than 1 in 8 patients became completely pain-free Systolic blood pressure improved by 14.0 mmHg TRANSCEND-T2D-1 Type 2 diabetes (40 weeks) Published March 2026