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10.1111/j.1432-1033.1974.tb03580.x [DOI] [PubMed] [Google Scholar] 31.Senderoff RI, Kontor KM, Kreilgaard L, Chang JJ, Patel S, Krakover J, et al

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The treatment effects of interest, including the differences in the respective primary endpoints of interest from baseline to the defined primary timepoint, will be summarized using an analysis of covariance (ANCOVA) for the treatment regimen estimand and a mixed model for repeated measures (MMRM) for the efficacy estimand, both with treatment and strata as fixed effects and the baseline response variable as a covariate

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