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But Ive also interviewed patients who stopped taking GLP-1s or tapered their doses after hitting a weight-loss goal who say theyve maintained their weight, at least in the short term

Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)

Research shows that GLP-1 decreases gastric emptying and intestinal motility through both peripheral and central nervous system mechanisms

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Scientists are investigating whether GLP-1 receptor agonists impact cellular stress responses within skin cells through the production of heat shock proteins (HSP) such as Hsp70