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J., Kang J

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A multinational, randomized, openlabel, treattotarget trial comparing insulin degludec and insulin glargine in insulinnave patients with type 2 diabetes mellitus

The key warning signs are: Severe, persistent upper abdominal pain that doesn't respond to position changes or over-the-counter remedies Pain radiating to the back this classic pancreatitis presentation distinguishes it from routine GI discomfort Pain accompanied by persistent vomiting that prevents keeping any fluids down Fever combined with abdominal pain suggests an inflammatory or infectious process Published guidelines from the European Association for the Study of Diabetes recommend that GLP-1 receptor agonist treatment should be stopped immediately when pancreatitis is suspected, pending full clinical evaluation

This risk was reduced even further in cases of prolonged treatment extending beyond three years (HR: 0.71), though GLP-1RA treatment for zero to one years (HR: 0.89) and one to three years (HR: 0.85) were not significant