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All pathological results confirmed that semaglutide alleviated hepatic lipid accumulation, inflammation, and fibrosis morphologically, and led to changes in mitochondrial structure

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Conversely, GLP-1 signaling influences estrogen receptor expression and activity

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However, their use may be limited by gastrointestinal side effects, including pancreatitis, though studies have reported safe co-administration with tacrolimus in kidney transplant recipients with post-transplant diabetes mellitus. Figure 2: Potential benefits of GLP1-RA in CKD and KTR