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1,2 This restriction is based on animal studies where semaglutide and tirzepatide caused thyroid C-cell tumours in rats

Zuckerman performs a variety of procedures each designed to address a particular area

Upon food ingestion and its subsequent entry into the small intestine, intestinal L-cells undergo posttranslational processing of the proglucagon gene, leading to the production of glucagon-like peptide-1 (GLP-1), a potent incretin peptide hormone 9

doi:10.1016/S2213-8587(15)00482-9 3

GLP-1 receptor agonists are medications that mimic a natural hormone in the body (glucagon-like peptide-1) to help regulate blood sugar and control appetite