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Interestingly, ghrelin requires acylation on its serine-3 residue by the enzyme GOAT in order for the peptide to bind to GHSR1a (Kojima et al., 1999

SNAC can non-covalently interact with peptide, forming a peptide/SNAC complex with increased lipophilicity able to permeate through the gastrointestinal epithelium via transcellular pathways [202]

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