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Current guidance recommends discontinuing semaglutide and tirzepatide at least two months before attempting conception due to the long half-life of these compounds in the body

Frequently Asked Questions Is heartburn a common side effect of semaglutide

Lowering the dose of GLP-1 receptor agonist or using a slower titration regimen may help to mitigate these effects

Figure 37: Photograph of Lotte Bjerre Knudsen, credit: Knudsen

16 Berenbaum hypothesized that the therapeutic potential of GLP-1 in OA may arise from targeting the crosstalk between macrophages and fibroblasts, which are known to drive inflammation, fibrosis, and downstream cartilage damage
