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However, besides prolonging the T max value of other medications, they do not usually affect the pharmacokinetic parameters of other drugs, such as area under curve (AUC) or maximum concentration (C max ) [46]

Healthcare professionals should provide comprehensive counselling about realistic expectations, potential side effects, and the importance of lifestyle modifications alongside pharmacotherapy for optimal outcomes in cardiometabolic health

Subsequently, things changed rapidly

The FDA has logged hundreds of hospitalizations and more than 20 deaths linked to these knockoff drugs

New formulations of GLP-1 receptor agonists with weekly injectable or oral administration were introduced in the 2010s [3]