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Several animal studies and preliminary human trials have suggested that allulose may influence postprandial glucose responses and potentially affect GLP-1 secretion, though the evidence base remains limited and requires further validation

Gastrointestinal distension by ISF significantly reduced short-term food intake without aversive behavior, and this effect was significantly attenuated by pretreatment with GLP-1R antagonist or chemical ablation of vagal sensory neurons (Fig