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PMID: 43 YoshijiSIwasakiYIwasakiKMegumiA-AHonjoSWadaYet al

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Metformin remains widely used due to its affordability and long safety record

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Metformin does not activate GLP-1 receptors and contains no GLP-1 compounds

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That study will provide insights into the potential of GLP-1 RAs to modify the disease course in HFpEF patients

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Note that a GLP-1-FGF21 fusion protein exhibits enhanced glycemic and body weight control superior to combination therapy using separate analogs of GLP-1 and FGF21 (Boettcher, B.R

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