semaglutide + cagrilintide Peptide Cagrilintide–semaglutide (CagriSema) as an add-on

Also, footwear must be tried on indoors

Method A literature search was performed in PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar during March 2025September 2025, using combinations of the following terms: GLP-1 receptor, GLP-1R agonist, GLP-1 signalling, semaglutide, liraglutide, exenatide, dulaglutide, salivary glands, xerostomia, hyposalivation, oral adverse effects, biased agonism, -arrestin, cAMP, GPCR signaling, albumin binding, pharmacovigilance

However, rapid weight loss itselfespecially loss exceeding 1-2 pounds weeklycan temporarily shift thyroid hormone metabolism and TSH levels, a phenomenon called weight-loss-related thyroid adaptation

Beyond weight loss, Semaglutide improves several metabolic health markers: Insulin Sensitivity: Improved insulin sensitivity can reduce the risk of insulin resistance, a condition often linked to cancer development

Patients should always work closely with their assigned provider to monitor their progress and health