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[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Xu L., Xu C., Liu X., Li X., Li T., Yu X., Xue M., Yang J., Kosmas C.E., Moris D., et al

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While the physiological relevance of irisin in humans is under investigation, growing preclinical evidence suggests its role in lipid metabolism, browning of white adipose tissue, and glucose uptake

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Randomized clinical trials (RCTs) are the optimal studies for determining cause and effect relationships

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28.7% weight loss at 12 mg, dysesthesia signal at the highest dose

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Punjabi et al., 2014

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