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23,24 A phase IIb RCT including 283 noncirrhotic NASH patients compared OCA and placebo groups for 72 weeks and showed that more patients in the OCA group had improvement in scored liver histology without progression of fibrosis from baseline

Rare Emerging Adverse Cutaneous Reactions Dermal Hypersensitivity The most reported cutaneous adverse drug reaction (ADR) occurring during GLP-1 RAs treatment is dermal hypersensitivity (DHS)

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation on offspring outcomes: A systematic review of the evidence

The results of a trial of semaglutide in obese patients with HFpEF showed a significant amelioration of symptoms and improvements in motor function and weight loss compared with patients treated with a placebo

By contrast, injectable semaglutide is administered weekly as a quick shot in the belly, which some may find more manageable