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Learn about the concerns regarding their use during early pregnancy.

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As reported at the 2026 Crohns and Colitis Congress, GLP-1 RAs are potentially beneficial as an adjunct to Crohns disease management for patients with overweight or obesity.

Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit