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If constipation is already becoming an issue, this guide pairs well with practical advice on managing GLP-1 medication constipation

Essential Lab Panel and Biomarker Framework for GLP-1 Readiness A comprehensive pre-GLP-1 assessment typically includes metabolic markers, renal function, thyroid status, and pancreatic enzymes

Mental stress should be addressed among individuals with obesity, as chronic stress may promote obesity development through the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation that elevates cortisol levels, interferes with insulin sensitivity, promotes energy storage, and creates food cravings for ultra-processed comfort foods [180] GLP-1s may act both centrally and peripherally to reduce these downstream impacts of chronic stress and obesity and alter food reward pathways in positive ways [124]