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If you've plateaued on semaglutide, switching to tirzepatide is a reasonable option to discuss

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For type 2 diabetes, NICE guideline NG28 recommends that continuation of GLP-1 receptor agonist therapy should be based on demonstrable benefit, specifically a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 5% of initial body weight at 6 months

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