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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked

Youve likely heard about glucagon-like peptide-1 agonists commonly referred to as GLP-1 medications, and more widely recognized through pharmaceutical brand names like Ozempic and Mounjaro.

Youve probably seen the headlines, heard the celebrity endorsements, or had a friend proudly say theyve finally dropped the weight that wouldnt budge

Expanded uses in inflammatory bowel disease, neurological diseases, and metabolic dysfunction-associated steatohepatitis (MASH)