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tirzepatide surmount-1 nejm 2022 weight loss percent SURPASS-2 (NEJM 2021) was the definitive head-to-head: vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions Tirzepatide after intensive lifestyle intervention
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lost 23kg after 4 months Dorothy A

This twofold activation creates a synergistic effect: GLP-1 handles appetite suppression while GIP enhances insulin secretion and energy expenditure

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