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For this drug, the ongoing SOUL trial has shown promising preliminary results, indicating a 14% reduction in the risk of MACE (84)
By reducing fat storage, glucagon appears to enhance the weight loss effects of GLP-1

Oral semaglutide represents a paradigm shift in GLP-1 therapy accessibility, with extensive real-world evidence from 19 studies confirming comparable effectiveness and tolerability to injectable formulations in routine clinical scenarios [65]

As a result, people frequently consume fewer calories, which, when paired with a nutritious diet and consistent exercise, results in long-term weight loss
At 10 years, the survival probability was 96.9% for GLP-1RA use and 76.4% for insulin/metformin use
