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However, renal effects of GLP-1 in heart failure (HF) has not been elucidated

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Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, primarily located in the upper small intestine, in response to food intake and plays a significant role in the postprandial regulation of nutrient metabolism

This is hard to accomplish with a juice concentrate, so I'm guessing these smoothies include at least 1 form of whole fresh fruit