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For example, specific GLP1R variants correlate with reduced appetite suppression and slower gastric emptyingtwo hallmarks of inadequate drug response

This makes it particularly dangerous for GLP-1 users, who are already dealing with a constellation of symptoms that can mask early B12 depletion

Nogi Y, Nagashima M, Terasaki M, Nohtomi K, Watanabe T, Hirano T

In an embryofetal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (1.0-, 5.2-, and 14.9-fold the MRHD) were administered throughout organogenesis, from Gestation Day 16 to 50

It was aimed to have an even distribution of male and female participants with 40% of each sex recruited into each group