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GLP-1R agonist effects on plasma renin levels are also inconclusive, being either unchanged [ 39 42 ] or decreased [ 43 ]

Therefore, although the weight loss may be welcomed, the facial side effects may be less appealing to many

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After 3 months, take a 2-month break before repeating

When the upper bound of the 2-sided 95% confidence interval falls between 1.3 and 1.8, a post-marketing safety trial will be required to document that the true CV risk does not exceed a 30% increase