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Potential downsides Although current dual and triple agonists have not seen any long-term harmful effects so far, it is a possibility worth considering, given the history of anti-obesity drugs

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The first option is currently the regimen of choice.35 In asymptomatic patients, a dose of 10U or 0.2U/kg in obese patients of basal insulin at bedtime may be used (Table 1)

Conclusions and Relevance In this cohort study of individuals with T2D, GLP-1 RA use was associated with a modestly increased risk of incident DR