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More serious but rare side effects include: Pancreatitis (inflammation of the pancreas) if suspected (severe, persistent abdominal pain that may radiate to the back, possibly with vomiting), stop taking Rybelsus and seek urgent medical attention Diabetic retinopathy complications particularly in those with pre-existing retinopathy and rapid improvement in blood glucose control Gallbladder disease (cholelithiasis or cholecystitis) Acute kidney injury usually secondary to dehydration from severe gastrointestinal side effects Hypersensitivity reactions including anaphylaxis and angioedema There have been concerns about thyroid C-cell tumours in animal studies, though the relevance to humans is considered uncertain and low

They bind to the same receptor but, unlike the natural hormone (which is broken down quickly), they resist rapid degradation - giving them a sustained effect on appetite and blood sugar regulation

Pills are likely easier to manufacture than injections, and some health experts hope they could be cheaper

However, a common hurdle many people face is semaglutide constipation

Retrieved from Palma-b, L., Tavares Marques, L., Bujan, J., et al