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Additionally, use caution when prescribing topiramate to pregnant women (increased risk of cleft palate) and to women on birth control pills (topiramate induces the metabolism of estrogen and can diminish the efficacy of the contraceptive)

Preliminary clinical evidence supports this hypothesisstudies in obese individuals treated with tirzepatide have shown a downward trend in the apneahypopnea index (AHI), suggesting that tirzepatide may have a beneficial effect on sleep-disordered breathing (28)

When sleep becomes disrupted, stress signaling through the braingut axis often increases, and sleep disturbance has been associated with worsening gastrointestinal symptoms

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