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Key points: In clinical trials, tirzepatide (Mounjaro) produced roughly double the average weight loss of liraglutide (Saxenda), though these were separate trials with different durations Tirzepatide at the 15 mg dose produced approximately 21% average weight loss over 72 weeks Liraglutide 3.0 mg produced approximately 8% average weight loss over 56 weeks Real-world data from Second Nature shows even greater results (22.1%) when tirzepatide is combined with behavioural support Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract

The timing of these symptoms is important: nausea and digestive issues are most pronounced during the initial weeks of treatment and following dose escalations

But profound, persistent weakness that worsens over weeks, particularly muscle-specific weakness that makes daily activities difficult, can indicate excessive lean tissue catabolism

Watch for issues with insulin and drugs that trigger insulin release like sulfonylureas or glinides, which raise your risk of low blood sugar

[DOI] [PubMed] [Google Scholar] 281.Wang, X