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In particular, neurons of the hindbrain found in the nucleus-tractus solitarius (NTS) secrete GLP-1 and activate hypothalamic neurons of the paraventricular nucleus (PVN), resulting in satiety (155, 156)

2024 found that psychedelic substances have demonstrated potential for treating drug addiction, especially AUD, mostly by modulating neuroplasticity in the brain. Both of these studies are speculative, although the evidence that they collected was promising

Understanding how and when to use GLP1s in the context of liver disease can offer clinicians a more nuanced approach that aligns treatment with underlying metabolic dysfunction rather than surface phenotypes

14 These AEs can significantly impact a patients quality of life, leading to decreased adherence, limitation of dose escalations, and, in some cases, treatment discontinuation

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