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Conversely, reducing doses without medical guidance when experiencing mild discomfort may prevent you from reaching therapeutic levels necessary for significant weight loss outcomes

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Anthropometric Changes Anthropometric parameters were assessed at baseline and at 3, 6, and 12 months following intervention for both groups

NICE recommends continuing metformin when adding a GLP-1 receptor agonist like semaglutide, as the combination addresses multiple aspects of metabolic dysfunction without significantly increasing hypoglycaemia risk when used alone

Data Availability Statement The datasets used and/or analysed in the current study are available upon reasonable request