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The mouse models included lean mice (C57BL/6J and NSY.B6- a / a ), obese diabetic mice (NSY.B6- Ay / a ), proglucagon-deficient mice ( Gcg -/-), glucose-dependent insulinotropic polypeptide (GIP) receptor-deficient mice ( Gipr -/-), and ATP-sensitive potassium channel (KATP channel)-deficient mice ( Kcnj11 -/-)

Trial registration ClinicalTrials.gov NCT05071950

Glucagon-like-peptide-1 receptor agonists (GLP-1s) have transformed weight management and treatment of chronic disease

Recently, the Food and Drug Administration officially approved semaglutide for the treatment of metabolic dysfunction-associated steatohepatitis in adults with moderate-to-advanced fibrosis
